Advanced Diet and Lifestyle Blood Test, from our experts to you.
Dr Sam Rodgers MBBS, MRCGP

Chief Medical Officer meet our doctors

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Who is
this test for?

Our advanced profile is ideal if you want to be proactive about your health and gain insights into how your changes to your lifestyle can influence your internal health.


What can I
learn from this test?

You can learn more about your liver and kidney function, cholesterol and diabetes status. As we've built on our Diet and Lifestyle Blood Test, you'll also check your cortisol for stress management and magnesium for athletic performance and recovery.


How do I
see my results?

Your results will be displayed on your online dashboard, making it simple for you to track the impact of any changes you make over time.


What's included?

Adrenal hormones
Cholesterol status
Diabetes
Gout risk
Iron status
Kidney health
Liver health
Minerals
Muscle health
Proteins
Vitamins
Select profile for more information

Cortisol Cortisol is a stress hormone produced by the adrenal glands. It is vital to survival given its role in functions such as immunity, regulating blood pressure and releasing insulin for blood sugar maintenance.
Total cholesterol Cholesterol is an essential fat (lipid) in the body. Although it has a bad reputation it has some important functions, including building cell membranes and producing a number of essential hormones including testosterone and oestradiol. Cholesterol is manufactured in the liver and also comes from the food we eat. Although there are a number of different types of cholesterol, the two main components of total cholesterol are HDL (high density lipoprotein) which is protective against heart disease and LDL (low density lipoprotein) which, in high levels, can contribute to cardiovascular disease. Your total cholesterol result on its own is of limited value in understanding your risk of heart disease; high levels of HDL cholesterol can cause a raised total cholesterol result but may actually be protective against heart disease. Equally, you can have a normal total cholesterol level but have low levels of protective HDL cholesterol. The most important factors are how much HDL and LDL cholesterol you have, and what proportion of your total cholesterol is made up of protective HDL cholesterol. We give a detailed breakdown of the components of your total cholesterol in the rest of this cholesterol profile.
LDL cholesterol LDL cholesterol (low-density lipoprotein) is a molecule made of lipids and proteins which transports cholesterol, triglycerides and other fats to various tissues throughout the body. Too much LDL cholesterol, commonly called 'bad cholesterol', can cause fatty deposits to accumulate inside artery walls, potentially leading to atherosclerosis and heart disease.
Non - HDL cholesterol Your total cholesterol is broken down into 2 main components; HDL (good) cholesterol and LDL (bad). There are more types of harmful cholesterol in your blood than just LDL - these include VLDL (very low-density lipoproteins) and other lipoproteins which are thought to be even more harmful than LDL cholesterol. Non-HDL cholesterol is calculated by subtracting your HDL cholesterol value from your total cholesterol. It therefore includes all the non-protective and potentially harmful cholesterol in your blood, not just LDL. As such, it is considered to be a better marker for cardiovascular risk than total cholesterol and LDL cholesterol. The recommended level of non-HDL cholesterol is below 4 mmol/L.
HDL cholesterol HDL cholesterol (high-density lipoprotein) is a molecule in the body which removes cholesterol from the bloodstream and transports it to the liver where it is broken down and removed from the body in bile. HDL cholesterol is commonly known as 'good cholesterol'.
Total cholesterol : HDL The cholesterol/HDL ratio is calculated by dividing your total cholesterol value by your HDL cholesterol level. It is used as a measure of cardiovascular risk because it gives a good insight into the proportion of your total cholesterol which is good (i.e. high-density lipoprotein HDL). Heart disease risk tools (such as QRisk) use the cholesterol/HDL ratio to calculate your risk of having a heart attack.
Triglycerides Triglycerides are a type of fat (lipid) that circulate in the blood. After you eat, your body converts excess calories (whether from fat or carbohydrates) into triglycerides which are then transported to cells to be stored as fat. Your body then releases triglycerides when required for energy.
HbA1c Haemoglobin A1c (HbA1c), also known as glycated haemoglobin, is a longer term measure of glucose levels in your blood than a simple blood glucose test. Glucose attaches itself to the haemoglobin in your red blood cells, and as your cells live for around 12-16 weeks, it gives us a good indication of the average level of sugar in your blood over a 3 month period.
Uric acid Uric acid is a waste product produced from the breakdown of chemical compounds called purines. Purine occurs naturally in the body, but it is also found in the food we eat - and in some foods more than others. In healthy individuals, uric acid is excreted by the kidneys in urine, however, if levels are too high to excrete, or if you have a problem metabolising purine, then uric acid can begin to accumulate and can be deposited as crystals in the bodily tissues. When this occurs in joints it causes the painful condition known as gout.
Iron Iron is a mineral that is essential for life. It is a component of haemoglobin, a protein in our red blood cells that is responsible for transporting oxygen around our body. If we don't have enough iron, our haemoglobin levels fall and we can't get sufficient oxygen to our cells. This can cause symptoms which include fatigue, dizziness, and shortness of breath. Serum iron is a very transient reading and can be influenced by the amount of iron-rich food in your diet in the days before your blood test. For this reason, iron is rarely looked at on its own, and is interpreted alongside other markers in an iron status test.
TIBC Total iron-binding capacity (TIBC) is a measure of the ability of your body to efficiently carry iron through the blood.
Transferrin saturation Transferrin is made in the liver and is the major protein in the blood which binds to iron and transports it round the body. This test measures how much this protein is 'saturated' by iron.
Ferritin Ferritin is a protein which stores iron in your cells and tissues. Usually, the body incorporates iron into haemoglobin to be transported around the body, but when it has a surplus, it stores the remaining iron in ferritin for later use. Measuring ferritin levels gives us a good indication of the amount of iron stored in your body.
Urea Urea is a waste product produced by the body when it breaks down proteins in the liver. Once the urea is made, it is transported to the kidneys, which filter it out of the blood and remove it from the body in the form of urine. Measuring the levels of urea in the blood can therefore reflect how well both the liver and the kidneys, are functioning. It is important to note that even if one kidney is severely damaged but the other is functioning perfectly, results may still return as normal.
Creatinine Creatinine is a chemical waste molecule that is generated from normal muscle metabolism. Measurement of this is an indicator of the levels of other waste products in the body. Creatinine is also an accurate marker of kidney function, and may help in diagnosing kidney disease.
eGFR The estimated glomerular filtration rate (eGFR) assesses how well the kidneys are working by estimating the amount of blood filtered through the kidneys. The glomeruli are tiny filters in the kidneys responsible for removing waste products. If these filters do not do their job properly, kidney function can be impaired. The eGFR calculation is an estimate of actual glomerular filtration rate, calculated using your age, gender, ethnicity, and serum creatinine levels.
Bilirubin Bilirubin is a product of the breakdown of haemoglobin from red blood cells. It is removed from the body via the liver, stored and concentrated in the gallbladder and secreted into the bowel. It is removed from your body through urine and faeces. Bilirubin causes the yellowish colour you sometimes see in bruises, due to red blood cells breaking down underneath the skin.
ALP Alkaline phosphatase (ALP) is an enzyme found mainly in the liver and bones. Measuring it can indicate ongoing liver, gallbladder or bone disease.
ALT Alanine transferase (ALT) is an enzyme which is mostly found in the liver, but is also found in smaller amounts in the heart, muscles and the kidneys. If the liver is damaged, ALT is leaked into to bloodstream. As ALT is predominantly found in the liver, it is usually an accurate marker for liver inflammation and can indicate liver damage caused by alcohol, fatty liver, drugs or viruses (hepatitis).
Gamma GT Gamma GT, also known as gamma-glutamyl transferase (GGT), is a liver enzyme which is raised in liver and bile duct diseases. It is used in conjunction with ALP to distinguish between bone or liver disease. Gamma GT is also used to diagnose alcohol abuse as it is raised in 75% of long term drinkers.
Magnesium - serum Magnesium is found in fibre-rich foods such as green leafy vegetables, avocados, bananas, wholemeal bread and brown rice as well as in fish and meat. Excess magnesium exposure can cause breathing problems, skin and eye irritation, flu-like symptoms and an upset stomach. Low magnesium can cause muscle aches and pains, fatigue, osteoporosis, an irregular heartbeat and high blood pressure. Low magnesium is associated with heart disease, artherosclerosis, stroke and diabetes.
Creatine kinase Creatinine kinase (CK) is an enzyme which is necessary for muscle function and is found in the heart and skeletal muscles as well as other tissues. It signifies muscle cell damage and death and is measured to diagnose and monitor muscle damage. CK levels tend to be higher in people with greater muscle mass.
Total protein Total Protein represents the sum of the proteins albumin and globulin in your blood. Albumin and globulin have a range of functions including keeping blood within vessels, transporting nutrients and fighting infection. Abnormal levels can indicate malnutrition as well as a liver or kidney disorder.
Albumin Albumin is a protein which is made mainly in the liver. It helps to exert the osmotic pressure which holds water within the blood. It also helps carry nutrients and medications and other substances through the blood and is important for tissue growth and healing. Albumin also carries hormones around the body, therefore measuring the amount of albumin in the blood can help us calculate how much hormone is available to your tissues.
Globulin Globulin is an umbrella term for a set of different proteins that the immune system and the liver produce. Certain globulins bind with haemoglobin while others transport metals, such as iron, in the blood. Additionally, there is a certain type of globulin known as an immunoglobulin, (another name for an antibody) which helps to fight infection in the body.
Folate - serum Folate is a B vitamin which acts as a coenzyme in the metabolism of amino acids. It is also vital for the synthesis of purines and pyrimidines which are essential for DNA synthesis and red cell formation. Folate is also especially important during the first trimester of pregnancy so if you are thinking of becoming pregnant it is important to make sure your folate levels are normal.
Vitamin B12 - active Vitamin B12 is important for production of red blood cells which carry oxygen around the body. B12 is also involved in metabolism and the nervous system and prolonged lack of vitamin B12 may cause nerve damage. Although Vitamin B12 is almost entirely found in animal-based foods, many vegetarian and vegan products, especially plant milks are now fortified with Vitamin B12.
Vitamin D Although called a vitamin, vitamin D is actually a hormone which is activated by sunshine on your skin. Vitamin D is essential for bone strength as it helps your intestines absorb calcium. However, it is thought that vitamin D also plays an important role in immune function, as well as in many chronic diseases and mental health. Many people in the UK have low levels of vitamin D with symptoms including muscle weakness, mood swings and fatigue. People who have dark skin, as well as those who don't spend much time outdoors are particularly at risk of low vitamin D. Small amounts of vitamin D can be obtained from food, especially oily fish, eggs and any food which has been fortified with vitamin D. If you are deficient in vitamin D you are unlikely to be able to improve your levels by food alone.

How to prepare
for your test

Special instructions

Prepare for your Advanced Diet and Lifestyle Blood Test by following these instructions. Please take your sample before 10am. Avoid heavy exercise for 48 hours beforehand. Avoid fatty foods for eight hours before your test, you do not need to fast. Hormonal contraception can affect this test, taking a break from this and using barrier contraception will give more accurate results. Corticosteroid medication can affect this test, ask your doctor whether to stop before testing. You should take this test before you take any medication or vitamin/mineral supplements. Do not take biotin supplements for two days before this test, discuss this with your doctor if it is prescribed. Do not take vitamin B12 for two weeks prior to this test. If your B12 is prescribed ask your doctor whether to stop.


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