Extractable Nuclear Antibodies (ENA) Blood Test, from our experts to you.
Dr Sam Rodgers MBBS, MRCGP

Chief Medical Officer meet our doctors

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What is an
ENA blood test?

Our Extractable Nuclear Antibodies (ENA) Blood Test detects the presence of one or more autoantibodies in the blood that react with proteins in the cell nucleus.


What tests
are included?

This panel includes tests for different antibodies, including:

  • -Anti-RNP antibodies to detect mixed connective tissue disease (MCTD)
  • -Anti-Sm antibodies for systemic lupus erythematosus (SLE)
  • -Anti-SS-A (Ro) and anti-SS-B (La) antibodies for Sjögren's syndrome
  • -Scl-70 antibodies for scleroderma (systemic sclerosis)
  • -Anti-Jo-1 for polymyositis

Who should
take this test?

This test is usually requested following a positive ANA test for people with signs and symptoms of an autoimmune disorder.


What's included?

Autoimmunity
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Anti CEN - P Antibodies
Anti Jo1 Antibodies
Anti La SS - B Antibodies
Anti Ro SS - A Antibodies
Anti Scl 70 Antibodies
Anti Sm Antibodies
Anti U1RNP Antibodies
Extractable Nuclear Antigen An extractable nuclear antigen (ENA) screen looks for the presence of one or more autoantibodies in the blood that react with proteins in the cell nucleus.  Autoantibodies are produced when the immune system mistakenly targets and attacks the body's own tissues which can cause inflammation, tissue damage and symptoms associated with an autoimmune disorder. The results of an ENA screen can help to detect and distinguish between different autoimmune disorders.

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