Coeliac Blood Test

Name: Coeliac Blood Test
Brand: Medichecks
SKU: M419
Price: 135.2 GBP
Availability: InStock

£135.20 ~~£169~~

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Worried that gluten might be affecting your health? If you’ve been experiencing symptoms like bloating, fatigue, or unexplained weight loss, our Coeliac Blood Test can help identify whether coeliac disease could be a concern. It checks for specific antibodies linked to the body’s immune response to gluten, helping to determine if you'd benefit from further confirmatory tests.

You must have been eating gluten-containing foods (with wheat, barley, or rye) in at least two meals per day for at least 6 weeks prior to testing.

Results in 2 working days (estimated)
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Measuring tissue transglutaminase IgA antibodies (tTG IgA) and total immunoglobulin A (IgA), which are commonly raised in people with coeliac disease and help assess whether further testing is needed.

How do you want to take your sample?

Book a venous draw at a clinic Venous
+£35

Visit one of our national clinic partners for a nurse to take your venous blood sample from a vein in your arm. We’ll email you instructions on how to book after we’ve processed your order.

Find my clinic
Book a venous draw at home with a nurse Venous
+£59

Book a home nurse appointment for a nurse to take your venous blood sample from a vein in your arm.
Self-arrange a professional sample collection Venous
Free

Make an appointment at a phlebotomy clinic to have your venous blood sample taken. You will be responsible for arranging your appointment and any additional fees.

Results only (without doctor's comments)

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Blood testing made easy

How it works

You have the flexibility to choose what works best for you. Enjoy the comfort of having a friendly nurse visit your home for a quick blood draw, opt for a convenient visit to one of our nationwide partner clinics, or self-arrange a draw at a location that suits you.

Take control of your health with Medichecks – order your blood test today!

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What's in the test?

Autoimmunity

T transglutaminase IgA

Learn more

Tissue transglutaminase IgA (tTGA) is an antibody made by the immune system in response to gluten in people with coeliac disease. It targets the enzyme tissue transglutaminase, which plays a role in repairing the gut lining. Raised levels are a strong indicator of an autoimmune reaction to gluten and are commonly used as a first-line screening tool for coeliac disease.

Immunity

Immunoglobulin A

Learn more

Immunoglobulins or antibodies, play an important role in the immune system and help fight against harmful bacteria and viruses in the body. There are five classes of antibodies and several subclasses. Immunoglobulin A or IgA protects against infections of the membranes that line the mouth, airways, and digestive tract. IgA antibodies can also be found in saliva, tears, and breast milk.

How to prepare for your test

Prepare for your Coeliac Blood Test by following these instructions.

Fasting and hydration

Eat gluten-containing foods in at least two meals every day for six weeks before this test.

Test limitations

This test does not diagnose coeliac disease. It’s a first-line screening tool that can indicate if further assessment is recommended.

To ensure accurate results, you must have been eating gluten-containing foods (with wheat, barley, or rye) in at least two meals per day for at least 6 weeks prior to testing.

It's possible to have coeliac disease and not have these antibodies in your blood. If you have persistent symptoms of coeliac disease, you may still need to see a specialist for further testing.

False-positive results can occasionally occur in people with other autoimmune conditions or gut disorders that trigger elevated antibody levels, even if coeliac disease isn’t present. That’s why a positive result doesn’t confirm diagnosis, it simply indicates that further investigation is needed.

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FAQs

What does the Coeliac Blood Test check for?

This test measures tissue transglutaminase IgA antibodies (tTGA) and total IgA levels. Elevated tTGA levels suggest an immune response to gluten, which may indicate coeliac disease. Total IgA is tested to ensure accurate interpretation of the results.

Do I need to eat gluten before taking this test?

Yes. To get reliable results, you must eat gluten (from foods like bread, pasta, or cereal made with wheat, barley, or rye) in at least two meals per day for at least 6 weeks before taking the test. This is really important to avoid a false-negative result (i.e. a negative result despite having coeliac disease).

Can this test diagnose coeliac disease?

No, this test can't diagnose coeliac disease. It’s a first step in the process. If your results suggest possible coeliac disease, you’ll likely need further blood tests or a gastroenterologist referral for further testing, usually including an intestinal biopsy.

What does a positive result mean?

A positive result means that your immune system has produced antibodies (tTGA IgA) that are often elevated in people with coeliac disease. This suggests your body may be reacting abnormally to gluten. While this doesn’t confirm a diagnosis, it means that you likely need further testing with a specialist. It's important to continue eating gluten until all follow-up testing is complete.

What does a negative result mean?

A negative result generally means that coeliac disease is unlikely, especially if you've been eating enough gluten in your diet before the test and your total IgA levels are normal. However, a negative result doesn’t always rule it out completely. If you have IgA deficiency, or weren’t eating gluten regularly before the test, you may need further testing. If symptoms continue despite a negative result, speak to your GP.

What happens if my test results are abnormal?

If your antibody levels are raised, it’s a sign that you may have coeliac disease. You should then be referred to a specialist for further evaluation and testing. It's important to continue eating gluten until all follow-up tests are complete.

What if I have low total IgA levels?

Low IgA levels can make the tTGA test less reliable. In these cases, additional IgG-based tests may be needed. In your doctor's report, we'll advise on next steps and whether further blood tests are required.

I’ve had a negative result in the past. Should I test again?

If you've developed new symptoms or have concerns despite a previous negative result, it may be worth re-testing, especially if you’ve been eating gluten regularly again.

Should I stop eating gluten if my test is positive?

Not yet. It’s important to continue eating gluten until a specialist confirms the diagnosis, usually through a biopsy. Stopping gluten too early can affect the accuracy of further testing.