Anti Sm Antibodies

Anti-Sm antibodies (anti-Smith antibodies) are highly specific autoantibodies associated with systemic lupus erythematosus (SLE). While not everyone with lupus has these antibodies, their presence is considered very specific to the condition. That means if they're found, it strongly suggests SLE. These antibodies target proteins that are part of the cell's machinery for processing genetic information. Testing for Anti-Sm antibodies can help confirm a lupus diagnosis and may be used alongside other tests to build a complete picture of autoimmune activity.