Anti Scl 70 Antibodies

Anti-Scl-70 antibodies (also called anti-topoisomerase I antibodies) are autoantibodies associated with systemic sclerosis (scleroderma), an autoimmune condition that causes thickening and hardening of the skin and can affect internal organs. These antibodies are particularly linked to the diffuse form of systemic sclerosis, which tends to affect larger areas of skin and has a higher risk of involving internal organs such as the lungs and kidneys. The presence of these antibodies can help confirm a diagnosis of systemic sclerosis and may indicate the need for careful monitoring of organ function.