Advanced TRT (Testosterone Replacement Therapy) Blood Test
    Advanced TRT (Testosterone Replacement Therapy) Blood Test
    Advanced TRT (Testosterone Replacement Therapy) Blood Test
    Advanced TRT (Testosterone Replacement Therapy) Blood Test

Advanced TRT (Testosterone Replacement Therapy) Blood Test

£119.20 £149
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Get an advanced check for your hormones, liver and kidney function, blood health and prostate if you are taking or considering testosterone replacement therapy (TRT).

  • Results estimated in 2 working days
  • Convenient testing options
  • Bespoke doctor’s report
  • Free delivery

How do you want to take your sample?

  • Book a venous draw at a clinic   Venous
    +£35

    Visit one of our national clinic partners for a nurse to take your venous blood sample from a vein in your arm. We’ll email you instructions on how to book after we’ve processed your order.

  • Book a venous draw at home with a nurse Venous
    +£59

  • Self-arrange a professional sample collection Venous
    Free

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Is it for you?

Do you take testosterone replacement therapy (TRT) and want to monitor your progress? Perhaps you're due to start treatment and want a baseline check of your liver, kidney and prostate health.

Our advanced TRT panel allows you to monitor your testosterone levels while assessing for common side effects of treatment.

Biomarker table

Cholesterol status

Total cholesterol

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Cholesterol is an essential fat (lipid) in the body. Although it has a bad reputation it has some important functions, including building cell membranes and producing a number of essential hormones including testosterone and oestradiol. Cholesterol is manufactured in the liver and also comes from the food we eat. Although there are a number of different types of cholesterol, the two main components of total cholesterol are HDL (high density lipoprotein) which is protective against heart disease and LDL (low density lipoprotein) which, in high levels, can contribute to cardiovascular disease. Your total cholesterol result on its own is of limited value in understanding your risk of heart disease; high levels of HDL cholesterol can cause a raised total cholesterol result but may actually be protective against heart disease. Equally, you can have a normal total cholesterol level but have low levels of protective HDL cholesterol. The most important factors are how much HDL and LDL cholesterol you have, and what proportion of your total cholesterol is made up of protective HDL cholesterol. We give a detailed breakdown of the components of your total cholesterol in the rest of this cholesterol profile.

LDL cholesterol

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LDL cholesterol (low-density lipoprotein) is a molecule made of lipids and proteins which transports cholesterol, triglycerides and other fats to various tissues throughout the body. Too much LDL cholesterol, commonly called 'bad cholesterol', can cause fatty deposits to accumulate inside artery walls, potentially leading to atherosclerosis and heart disease.

Non-HDL cholesterol

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Your total cholesterol is broken down into 2 main components; HDL (good) cholesterol and LDL (bad). There are more types of harmful cholesterol in your blood than just LDL - these include VLDL (very low-density lipoproteins) and other lipoproteins which are thought to be even more harmful than LDL cholesterol. Non-HDL cholesterol is calculated by subtracting your HDL cholesterol value from your total cholesterol. It therefore includes all the non-protective and potentially harmful cholesterol in your blood, not just LDL. As such, it is considered to be a better marker for cardiovascular risk than total cholesterol and LDL cholesterol. The recommended level of non-HDL cholesterol is below 4 mmol/L.

HDL cholesterol

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HDL cholesterol (high-density lipoprotein) is a molecule in the body which removes cholesterol from the bloodstream and transports it to the liver where it is broken down and removed from the body in bile. HDL cholesterol is commonly known as 'good cholesterol'.

Total cholesterol : HDL

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The cholesterol/HDL ratio is calculated by dividing your total cholesterol value by your HDL cholesterol level. It is used as a measure of cardiovascular risk because it gives a good insight into the proportion of your total cholesterol which is good (i.e. high-density lipoprotein HDL). Heart disease risk tools (such as QRisk) use the cholesterol/HDL ratio to calculate your risk of having a heart attack.

Triglycerides

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Triglycerides are a type of fat (lipid) that circulate in the blood. After you eat, your body converts excess calories (whether from fat or carbohydrates) into triglycerides which are then transported to cells to be stored as fat. Your body then releases triglycerides when required for energy.

Clotting status

Platelet count

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Platelets or clotting cells are the smallest type of blood cell. They are formed in the bone marrow and are important in blood clotting. When bleeding occurs, the platelets swell, clump together and form a sticky plug (a clot) which helps stop the bleeding.

Diabetes

HbA1c

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Haemoglobin A1c (HbA1c), also known as glycated haemoglobin, is a longer-term measure of glucose levels in your blood than a simple blood glucose test. Glucose attaches itself to the haemoglobin in your red blood cells, and as your cells live for around 12-16 weeks, it gives us a good indication of the average level of sugar in your blood over a 3-month period.

A raised HbA1c result points to diabetes or an increased risk of developing diabetes, which can have a significant impact on your lifespan and quality of life. Complications of uncontrolled diabetes include heart disease, kidney disease, eye problems, and vascular conditions. It can also contribute to mental health problems. And men with diabetes are three times more likely to have erectile dysfunction. Keeping your HbA1c within a normal range can help you reduce the risk of these conditions.

Hormones

FSH

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Follicle Stimulating Hormone (FSH) is produced in the pituitary gland and is important for women in the production of eggs by the ovaries and for men in the production of sperm. In the first half of the menstrual cycle in women, FSH stimulates the enlargement of follicles within the ovaries. Each of these follicles will help to increase oestradiol levels. One follicle will become dominant and will be released by the ovary (ovulation), after which follicle stimulating hormone levels drop during the second half of the menstrual cycle. In men, FSH acts on the seminiferous tubules of the testicles where they stimulate immature sperm cells to develop into mature sperm.

LH

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Luteinising Hormone (LH) is produced by the pituitary gland and is important for male and female fertility. In women it governs the menstrual cycle, peaking before ovulation. In men it stimulates the production of testosterone.

Oestradiol

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Oestradiol is the strongest of the three oestrogens. It's labelled a female hormone but it's made in both the ovaries and testes. It's responsible for the growth of breast tissue, the female reproductive system, and male sexual function.

In pre-menopausal women, oestradiol levels vary throughout the monthly cycle, peaking just before ovulation. Levels are lowest after menopause when the ovaries stop producing eggs. Low oestradiol levels in women can cause many symptoms associated with the menopause, including hot flushes, night sweats, and changes in mood. It can also increase the risk of osteoporosis (a condition where the bones become less dense).

In men, oestradiol levels tend to increase slightly with age as testosterone levels decline. Too much oestradiol in men can contribute to fertility problems, gynecomastia (enlarged breast tissue), and erectile dysfunction.

Testosterone

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Testosterone is a hormone that causes male characteristics. For men, it helps to regulate sex drive and has a role in controlling bone mass, fat distribution, muscle mass, strength and the production of red blood cells and sperm. Testosterone is produced in the testicles of men and, in much smaller amounts, in the ovaries of women. Testosterone levels in men naturally decline after the age of 30, although lower than normal levels can occur at any age and can cause low libido, erectile dysfunction, difficulty in gaining and maintaining muscle mass and lack of energy. Although women have much lower amounts of testosterone than men, it is important for much the same reasons, playing a role in libido, the distribution of muscle and fat and the formation of red blood cells. All laboratories will slightly differ in the reference ranges they apply because they are based on the population they are testing. The normal range is set so that 95% of men will fall into it. For greater consistency, we use the guidance from the British Society for Sexual Medicine (BSSM) which advises that low testosterone can be diagnosed when testosterone is consistently below the reference range, and that levels below 12 nmol/L could also be considered low, especially in men who also report symptoms of low testosterone or who have low levels of free testosterone.

Free testosterone - calc

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Most testosterone circulating in the blood is bound to proteins, in particular SHBG and albumin; only 2-3 % of testosterone is free and available to cells. This test uses an algorithm to calculate the level of free or unbound testosterone in relation to total testosterone, SHBG and albumin.

Prolactin

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Prolactin is a hormone which is produced in the pituitary gland and plays a role in reproductive health. Its primary purpose is to stimulate milk production after childbirth, and in pregnant and breastfeeding women prolactin levels can soar.

Iron status

Ferritin

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Ferritin is a protein which stores iron in your cells and tissues. Usually, the body incorporates iron into haemoglobin to be transported around the body, but when it has a surplus, it stores the remaining iron in ferritin for later use. Measuring ferritin levels gives us a good indication of the amount of iron stored in your body.

Kidney health

Creatinine

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Creatinine is a chemical waste molecule that is generated from normal muscle metabolism. Measurement of this is an indicator of the levels of other waste products in the body. Creatinine is also an accurate marker of kidney function, and may help in diagnosing kidney disease.

eGFR

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The estimated glomerular filtration rate (eGFR) assesses how well the kidneys are working by estimating the amount of blood filtered through the kidneys. The glomeruli are tiny filters in the kidneys responsible for removing waste products. If these filters do not do their job properly, kidney function can be impaired. The eGFR calculation is an estimate of actual glomerular filtration rate, calculated using your age, gender, ethnicity, and serum creatinine levels.

Liver health

ALP

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Alkaline phosphatase (ALP) is an enzyme found mainly in the liver and bones. Measuring it can indicate ongoing liver, gallbladder or bone disease.

ALT

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Alanine transferase (ALT) is an enzyme which is mostly found in the liver, but is also found in smaller amounts in the heart, muscles and the kidneys. If the liver is damaged, ALT is leaked into to bloodstream. As ALT is predominantly found in the liver, it is usually an accurate marker for liver inflammation and can indicate liver damage caused by alcohol, fatty liver, drugs or viruses (hepatitis).

Gamma GT

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Gamma GT, also known as gamma-glutamyl transferase (GGT), is a liver enzyme which is raised in liver and bile duct diseases. It is used in conjunction with ALP to distinguish between bone or liver disease. Gamma GT is also used to diagnose alcohol abuse as it is raised in 75% of long term drinkers.

Prostate

PSA - total

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Prostate Specific Antigen (PSA) is a protein which is released into the blood by the prostate gland. Prostate cancer can raise PSA levels but a PSA test in isolation is not to be relied upon to diagnose prostate cancer, as levels can be raised in benign prostate disorders (a false positive). There is also the potential for PSA levels to be normal despite the presence of prostate cancer, this is called a false negative.

Proteins

Total protein

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Total Protein represents the sum of the proteins albumin and globulin in your blood. Albumin and globulin have a range of functions including keeping blood within vessels, transporting nutrients and fighting infection. Abnormal levels can indicate malnutrition as well as a liver or kidney disorder.

Albumin

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Albumin is a protein which is made mainly in the liver. It helps to exert the osmotic pressure which holds water within the blood. It also helps carry nutrients and medications and other substances through the blood and is important for tissue growth and healing. Albumin also carries hormones around the body, therefore measuring the amount of albumin in the blood can help us calculate how much hormone is available to your tissues.

Globulin

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Globulin is an umbrella term for a set of different proteins that the immune system and the liver produce. Certain globulins bind with haemoglobin while others transport metals, such as iron, in the blood. Additionally, there is a certain type of globulin known as an immunoglobulin, (another name for an antibody) which helps to fight infection in the body.

SHBG

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SHBG (sex hormone binding globulin) is a protein which transports the sex hormones (testosterone, oestrogen and dihydrotestosterone (DHT)) in the blood.Hormones which are bound to SHBG are inactive which means that they are unavailable to your cells. Measuring the level of SHBG in your blood gives important information about your levels of free or unbound hormones which are biologically active and available for use.

Red blood cells

Haemoglobin

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Haemoglobin is a protein in red blood cells which carries oxygen around the body and gives the blood its red colour. This test measures the amount of haemoglobin in the blood and is a good measure of the blood's ability to carry oxygen around the body.

Haematocrit

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HCT (haematocrit) measures the amount of space (volume) within the blood that is taken up by red blood cells.

Red cell count

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Red Blood Cell (RBC) Count analyses the number of red blood cells in the blood. Red blood cells carry oxygen from the lungs to the rest of the body, where it can be used to fuel energy processes such as movement and respiration. They also carry carbon dioxide produced from cells back to the lungs so that it can be exhaled.

MCV

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MCV (mean corpuscular volume) reflects the average size of your red blood cells. This is important to measure, as it can indicate how much oxygen your cells are likely to be transporting around the body.

MCH

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MCH (mean corpuscular haemoglobin) measures the average amount of haemoglobin contained in one of your red blood cells.

MCHC

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MCHC (mean corpuscular haemoglobin concentration) is the average concentration of haemoglobin in your red blood cells. Haemoglobin is a molecule which allows red blood cells to transport oxygen around the body.

RDW

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Red blood cell distribution width (RDW) indicates whether your red blood cells are all the same size, or different sizes or shapes. Normally cells are fairly uniform both in size and in shape, but some blood disorders may cause your red blood cells to form in abnormal sizes. This test measures the difference between the largest and the smallest red blood cell.

Thyroid hormones

TSH

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Thyroid stimulating hormone (TSH) is produced in the pituitary gland in order to regulate the production of thyroid hormones thyroxine (T4) and triiodothyronine (T3) by the thyroid gland. If thyroid hormones in the blood are low, then more TSH is produced to stimulate the thyroid gland to produce more of them. If thyroid hormone levels are high, then the pituitary produces less TSH to slow the production of thyroid hormones. If TSH is too high or too low, it normally signifies that there is a problem with the thyroid gland which is causing it to under or over produce thyroid hormones. Sometimes a disorder of the pituitary gland can also cause abnormal TSH levels.

Free T3

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Triiodothyronine (T3) is the more active of the two thyroid hormones produced by the thyroid gland. Most T3 is bound to protein in the blood. Free T3 measures the level of T3 that is free, or unbound to protein, and is available to regulate metabolism.

Free thyroxine

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Thyroxine (T4) is one of two hormones produced by the thyroid gland. It works to speed up the rate of your metabolism. Most T4 is bound to carrier proteins in the blood - it is only the free, or unbound, T4 that is active in the body, which is measured in this test. Free T4 is the less active of the two main thyroid hormones. To have an impact on your cells it needs to convert to the more active T3 when your body needs it.

White blood cells

White cell count

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White Blood Cell (WBC) Count measures the number of white blood cells in the blood. White blood cells are key to your body's immune system. They fight infections and protect your body from foreign invaders such as harmful germs and bacteria. Additionally, they produce many antibodies and memory cells to protect you from further infections with the same germ.

Neutrophils

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Neutrophils are the most abundant type of white blood cell in the body and are responsible for helping your body fight infection. When a germ is initially detected by the body, neutrophils are the defence system which go out and attack the germ before any of your other white blood cells. When neutrophils are low you can be more vulnerable to illness and infection.

Lymphocytes

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Lymphocytes are a type of white blood cell which fight bacterial and viral infections. They are the subset of white blood cells involved in the more specific response to infections, which can identify and differentiate between different foreign organisms that enter the body. As well as fighting infection, they produce antibodies and memory cells to help to prevent future infections from the same germ. Lymphocytes include T cells, B cells and natural killer cells.

Monocytes

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Monocytes are a type of white blood cell that surround and destroy germs and dead or damaged cells from the blood. The heat and swelling that you feel when a body part is inflamed, for example after a cut on your finger, is caused by the activities of these cells.

Eosinophils

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Eosinophils are a type of white blood cell that are responsible for removing parasitic infections and regulating inflammation to mark an infected site. They also play a role in allergy and in asthma.

Basophils

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Basophils are a type of white blood cell that protect your body from bacteria and parasites such as ticks. They also play a role in allergic reactions.
Your health, simplified

Personalised doctor’s report

Get more than just results—get answers. Our personalised doctor’s report breaks down your results, explains how they compare to normal ranges, and offers clear, actionable insights into your health.

See a sample report
Special instructions

How to prepare for your test

Prepare for your Advanced TRT (Testosterone Replacement Therapy) Blood Test by following these instructions. Take your sample between 6am and 10am. Avoid vigorous exercise, ejaculation, or direct prostate stimulation (e.g. a rectal examination or receptive anal sex) for 48 hours beforehand – all of these can raise your PSA level. Avoid nipple stimulation or heavy meals before taking the test, as these can increase prolactin levels. Wait at least six weeks before taking this test if you've had a urine infection, prostatitis (prostate infection), or urological intervention (e.g. prostate biopsy or cystoscopy). Please let us know in the supporting information if you take testosterone replacement therapy (TRT), finasteride, dutasteride, or saw palmetto, as these can also affect your results. Take this test when any symptoms of short-term illness have settled. Avoid fatty foods for eight hours before your test, you do not need to fast. Stay well hydrated before your test. Take your sample at least 24 hours after any vitamin or mineral supplements. Do not take biotin supplements for two days before this test, discuss this with your doctor if it is prescribed. If you take thyroxine, you can take your medication as usual, either before or after your blood test. However, if you take desiccated thyroid extract (DTE) or liothyronine, it's best to take it after you've collected your sample. Please let us know in your supporting information if you take amiodarone or lithium as these can affect your thyroid function results.

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FAQs

What is TRT?

Testosterone replacement therapy is a treatment for testosterone deficiency – also known as hypogonadism. It occurs in men when the body doesn’t produce enough testosterone and can lead to symptoms such as low sex drive and erectile problems, lack of energy and low mood as well as decreased muscle mass and bone density and increased body fat.

What’s included in the TRT blood test panel?
The Advanced TRT Blood Test includes tests for a range of hormones (to monitor changes caused by testosterone supplementation), full blood count (to track red blood cell production) and other markers which are likely to be affected by treatment including liver and kidney function and cholesterol. It also includes a test for prostate-specific antigen (PSA), a protein which can be raised in cases of prostate cancer (although it can be raised in benign conditions as well).

What is the Advanced TRT Blood Test?
Our Advanced TRT (Testosterone Replacement Therapy) Blood Test measures markers in your blood which can help you to monitor and manage your testosterone replacement therapy.

What does TRT mean?

TRT stands for testosterone replacement therapy. It is a form of treatment for men with testosterone deficiency who are also experiencing symptoms of low T. These include reduced sex drive, problems maintaining an erection, low mood, loss of muscle mass and gaining body fat. It involves taking exogenous testosterone (testosterone which is not produced naturally in the body), either in the form of a gel, tablet or by injection.

Why do I need to test before and during TRT?

Taking testosterone supplements can significantly influence other processes in your body – notably hormone and red blood cell production, but also liver and kidney function and cholesterol levels. It is important to test before starting TRT to establish your normal levels for these markers and then again during treatment to monitor the effects of supplementation.

How often should I test during TRT?

We recommend that you test before your TRT begins and then again 6 months later to monitor the effects of treatment.

How can I reduce my haematocrit level on TRT?

There are various ways to reduce haematocrit while on TRT including giving blood, lowering your dose or changing to a topical cream or gel. If you want to donate blood, please do so under medical supervision and ensure that your haematocrit is within acceptable levels for the donation centre.

Will TRT affect my fertility?

A common side effect of TRT is a low sperm count or infertility (the inability to conceive). Taking testosterone medication or supplements can affect other hormones in your body and suppresses the release of LH and FSH, leading to decreased sperm production. However, fertility issues caused by TRT are usually reversible.

Our TRT profile checks male reproductive hormones, including FSH, LH, and prolactin, and can help you monitor the effects TRT may have on your fertility.

Will my fertility improve again after TRT?

In most cases sperm count and quality recovers to previous levels once treatment has finished. This process can take time though and depending on the duration and dose used in treatment it may take 12 months or more to get back to normal. In some cases TRT permanently impacts fertility which may limit the ability to conceive in future.

Can TRT increase my risk of prostate cancer?

While current research indicates that TRT is unlikely to increase your risk of prostate cancer, caution is still advised, particularly for men who already have prostate cancer.

We recommend having a physical examination of your prostate gland before starting TRT and monitoring your prostate-specific antigen (PSA) level during your treatment.

However, you should be aware of the shortcomings in PSA testing. For more information on testing PSA, read our guide: what is PSA and should I test it?

Can this test tell me if TRT is right for me?

TRT can have a positive, life-changing effect for men with low natural levels of testosterone, but it’s not right for everyone.

Our test can confirm if you have low testosterone, but you’ll need to show symptoms of testosterone deficiency to be eligible for TRT.

The British Society for Sexual Medicine recommends that treatment is not given to men with certain stages of prostate cancer, breast cancer, high haematocrit (the percentage of red cells in your blood), severe chronic heart failure, or a desire to have children.

This profile includes tests for haematocrit and PSA, a protein that can be raised in prostate cancer, although PSA can be raised in benign conditions too.

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