Intrinsic Factor Antibodies Blood Test, from our experts to you.
Dr Sam Rodgers MBBS, MRCGP

Chief Medical Officer meet our doctors

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What is
intrinsic factor?

Intrinsic factor is a glycoprotein produced by the parietal cells in your stomach - and it is necessary to absorb vitamin B12 from the food you eat. Interference in the production or the activity of intrinsic factor can reduce vitamin B12 being absorbed in the small bowel, resulting in anaemia.

What can I learn
from this test?

Our blood test identifies whether antibodies to intrinsic factor are present in your blood. If they are, it would indicate pernicious anaemia, an autoimmune condition.

What is
pernicious anaemia?

Pernicious anaemia causes a deficiency in vitamin B12, an essential water-soluble vitamin found in virtually all meat products and certain algae, such as seaweed. It helps maintain healthy nerve and red blood cells and is required to make DNA, the genetic material in all cells. Symptoms of pernicious anaemia include fatigue, shortness of breath, brittle nails, pins and needles, and cognitive difficulties (brain fog). Symptoms of pernicious anaemia can become debilitating and cause lasting damage if not caught early enough. Pernicious anaemia can be treated by regular vitamin B12 injections.

What's included?

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Intrinsic factor antibodies Intrinsic factor is produced in the stomach and helps extract vitamin B12 from the foods we eat. Interference in its production or activity can reduce the absorption of vitamin B12. Intrinsic factor antibodies are produced by the immune system. Intrinsic factor is necessary to extract vitamin B12 from the food we eat. Without sufficient intrinsic factor available, vitamin B12 is unabsorbed and the body cannot produce enough red blood cells which leads to the autoimmune condition pernicious anaemia.

How to prepare
for your test

Special instructions

Prepare for your Intrinsic Factor Antibodies Blood Test by following these instructions. Do not take vitamin B12 for two weeks prior to this test. If your B12 is prescribed ask your doctor whether to stop.

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