Intrinsic Factor Antibodies Blood Test
    Intrinsic Factor Antibodies Blood Test
    Intrinsic Factor Antibodies Blood Test
    Intrinsic Factor Antibodies Blood Test

Intrinsic Factor Antibodies Blood Test


Check for the presence of intrinsic factor antibodies in your blood which can indicate autoimmune gastritis (or pernicious anaemia if you are anaemic).

Results estimated in 5 working days

View 1 Biomarkers

How do you want to take your sample?

Please choose one option below
  • Book a venous draw at a clinic   +£35.00

    Visit one of our national clinic partners for a nurse to take your venous blood sample from a vein in your arm. We’ll email you instructions on how to book after we’ve processed your order.
  • Book a venous draw at home with a nurse +£59.00

  • Self-arrange a professional sample collection Free

Intrinsic Factor Antibodies Blood Test

Find your nearest clinic
Key: You are here Appointment required Walk-in service

Biomarker table


Intrinsic factor antibodies

Learn more

Intrinsic factor is produced in the stomach and helps extract vitamin B12 from the foods we eat. Interference in its production or activity can reduce the absorption of vitamin B12. Intrinsic factor antibodies are produced by the immune system. Intrinsic factor is necessary to extract vitamin B12 from the food we eat. Without sufficient intrinsic factor available, vitamin B12 is unabsorbed and the body cannot produce enough red blood cells which leads to the autoimmune condition pernicious anaemia.
Special instructions

How to prepare for your test

Prepare for your Intrinsic Factor Antibodies Blood Test by following these instructions. Do not take vitamin B12 for two weeks prior to this test. If your B12 is prescribed ask your doctor whether to stop.

Blood testing made easy

How it works

Your personalised, actionable health results are only a few clicks away. Order your test, take and post your sample, then view your results online with our doctors' comments.

Your results, simplified

Track, improve, and monitor your health over time

MyMedichecks is your personal online dashboard where you can view your results, access clear and simple explanations about individual health markers, monitor changes in your health, and securely store information about your medical history, lifestyle, and vital statistics.


What can I learn from this test?

This test checks whether you have antibodies to intrinsic factor in your blood. These antibodies can lead to vitamin B12 deficiency and eventually pernicious anaemia, an autoimmune condition. If your intrinsic factor antibody levels are raised, you may need further tests to confirm your diagnosis, such as gastric parietal cell antibodies, vitamin B12 and MMA levels, and a full blood count to check for anaemia. Please note that titre levels are only provided for positive results.

What is pernicious anaemia?

Pernicious anaemia causes a deficiency in vitamin B12, an essential water-soluble vitamin found in virtually all meat products and certain algae, such as seaweed. It helps maintain healthy nerve and red blood cells and is required to make DNA, the genetic material in all cells. Symptoms of pernicious anaemia include fatigue, shortness of breath, brittle nails, pins and needles, and cognitive difficulties (brain fog). Symptoms of pernicious anaemia can become debilitating and cause lasting damage if not caught early enough. Pernicious anaemia can be treated by regular vitamin B12 injections.

What is intrinsic factor?

Intrinsic factor is a glycoprotein produced by the parietal cells in your stomach - and it is necessary to absorb vitamin B12 from the food you eat. Interference in the production or the activity of intrinsic factor can reduce vitamin B12 being absorbed in the small bowel, resulting in anaemia.

Limitations of the test

Read before you order:

Up to half of people with autoimmune gastritis or pernicious anaemia have a negative result, known as a false-negative result. This is especially true in the early stages of the disease where antibody levels are much lower. It’s also possible to receive a positive result even without having pernicious anaemia but this is less common. This test can’t detect the stage or severity of pernicious anaemia. It’s also not a diagnostic test – you will likely require further investigative tests if you receive a positive result.

Our latest customer reviews