Epstein-Barr Virus Antibodies Blood Test

EBNA IgG antibodies (Epstein-Barr Nuclear Antigen IgG) are antibodies produced by the immune system in response to Epstein-Barr virus (EBV), the virus that causes glandular fever (infectious mononucleosis). These antibodies typically appear several months after infection and remain detectable for life, indicating past infection with EBV. The presence of EBNA IgG antibodies means you have developed long-term immunity from primary infection, although it's possible for the virus to reactivate later in life, particularly if the immune system is weakened. This test helps distinguish between recent and past EBV infection, which can be useful when investigating persistent fatigue or other symptoms.

EBV VCA IgM antibodies (Epstein-Barr Virus Capsid Antigen IgM) are produced by your immune system during an active or recent infection with Epstein-Barr virus, which causes glandular fever (infectious mononucleosis). These antibodies typically appear when symptoms first develop and usually disappear within a few months after infection. The presence of VCA IgM antibodies indicates current or recent EBV infection and can help diagnose acute glandular fever. This test is particularly useful if you're experiencing symptoms such as severe fatigue, sore throat, swollen lymph nodes, or fever.