Our most comprehensive thyroid profile taking a complete look at thyroid function, ferritin, folate, vitamin B12, vitamin D and reverse T3.
This comprehensive profile includes tests for TSH, thyroid hormones (T4, FT4, FT3) and thyroid antibodies (thyroglobulin antibodies and thyroid peroxidase antibodies) for a thorough investigation into your thyroid status and autoimmune disorders which could be causing your symptoms.
It also includes tests for iron storage (ferritin) which can be low in individuals with thyroid disease, key nutrients folate and vitamin B12, as well as inflammation marker high-sensitivity C-Reactive protein.
Vitamin D, important for immune function, is also included in this profile as is reverse T3 (rT3) - an inactive thyroid hormone which blocks the action of T3 in your cells. Some practitioners believe that raised rT3 may explain why people suffer from symptoms of hypothyroidism when their active thyroid hormones are within the normal ranges.
Thyroid Stimulating Hormone is produced in the pituitary gland and stimulates the thyroid gland to produce thyroid hormones thyroxine (T4) and triiodothyronine (T3).
High levels of TSH indicate an underactive thyroid while low levels indicate an overactive thyroid. In primary pituitary failure, a low TSH will be associated with an underactive thyroid.
Thyroxine (T4) is one of two hormones produced by the thyroid gland. Most T4 is bound to carrier proteins in the blood - this test measures the level of T4 which is free, or unbound, circulating in your blood.
High levels of free thyroxine can indicate an overactive thyroid while low levels can indicate an underactive thyroid.
T4 (Thyroxine) is the main hormone produced by the thyroid gland. T4 is not biologically active, and must be converted to T3 before it can become active in regulating metabolism. Some T4 is bound to proteins, while some T4 is 'free' or unbound. This test measures the level of total T4 in your blood.
Raised T4 can indicate an overactive thyroid while low T4 may indicate that the thyroid is struggling to produce sufficient thyroid hormones.
Triiodothyronine (T3) is one of two thyroid hormones produced by the thyroid gland. Most T3 is bound to protein in the blood. Free T3 measures the level of T3 that is free, or unbound to protein, and is available to regulate metabolism.
Normally T4 is converted to T3, the biologically active thyroid hormone. However, when the body is under stress (due to illness, starvation, extreme cold), it converts T4 to reverse T3 (rT3) which inhibits the action of T3 in our cells. This is thought to be a protective mechanism to conserve energy.
Low levels of rT3 are normal. A raised rT3 result may indicate that your cells are not receiving enough active T3, causing symptoms of hypothyroidism (underactive thyroid).
The rT3 ratio measures the level of reverse T3 in relation to free T3 in your blood. A low ratio indicates that the balance is favouring rT3, potentially leaving you with insufficient levels of active thyroid hormones in your cells. Some experts believe that a low ratio will lead to symptoms of hypothyroidism even when thyroid hormones are at normal levels.
This test looks for antibodies to thyroglobulin, a protein which is specific to the thyroid gland. Under normal circumstances it does not enter the bloodstream, but if your thyroid is inflamed or under attack from the body's own immune system, then thyroglobulin can be secreted and antibodies detected.
Raised levels of thyroglobulin antibodies (TGAb) can indicate autoimmune thyroid disease.
Thyroid peroxidase is an enzyme which is produced in the thyroid gland and is important for converting T4 to the biologically active T3. This test looks for antibodies to thyroid peroxidase (TPOAb) in the blood which indicates that the body's immune system is attacking the thyroid gland and impairing its function.
Raised levels of thyroid peroxidase antibodies are often found in Hashimoto's disease (underactive thyroid) and can sometimes be detected before any symptoms are reported.
Raised levels are also found in over half the cases of Graves' disease (overactive thyroid).
Vitamin B12 is important for production of red blood cells which carry oxygen around the body - low levels can cause anaemia with associated symptoms of lack of energy and fatigue. It is also involved in metabolism and the nervous system and prolonged lack of vitamin B12 may cause nerve damage. Vitamin B12 is almost entirely found in animal foods.
Raised levels of vitamin B12 can indicate a blood or liver disorder.
Low levels are seen in people with pernicious anaemia, an autoimmune disease which prevents the absorption of vitamin B12 or through dietary restriction e.g. a vegan diet.
Folate is a measure of the body's store of the vitamin folate, also known as folic acid. Folate is a water soluble vitamin which means you need it in your diet every day. It plays a role in DNA creation and is important for the production of red blood cells as well as in the prevention of neural tube defects in babies.
Low levels can indicate anaemia and can be implicated in raised homocysteine levels.
Although called a vitamin, vitamin D is actually a hormone which is activated by sunshine on your skin. Vitamin D is essential for bone strength as it helps your intestines absorb calcium. However, it is thought that vitamin D also plays an important role in immune function, as well as in many chronic diseases and mental health.
Many people in the UK do not produce enough Vitamin D, especially in the winter months with fewer daylight hours. It is now recommended that you get 10 - 15 minutes of unprotected sun exposure every day to ensure you are producing enough vitamin D. In winter months, if your levels are found to be low, you may wish to take a supplement.
C-Reactive Protein (CRP) is an inflammation marker used to assess whether there is inflammation in the body - it does not identify where the inflammation is located. High Sensitivity CRP (CRP-hs) is a test which is used to detect low-level inflammation which is thought to damage blood vessels and can lead to a heart attack or stroke.
Raised levels are a risk factor for cardio-vascular disease.
Ferritin is a protein which stores iron in your cells for your body to use later. Measuring ferritin levels gives us a good indication of the amount of iron stored in your body.
Low levels of ferritin can indicate anaemia which can be caused by excessive or chronic bleeding, poor absorption of iron or too little iron in the diet.
Raised ferritin levels can indicate iron overload syndrome (haemochromatosis) or any kind of liver damage. It is also a marker of infection and inflammation.
We will send you your Thyroid Check UltraVit rT3 blood and sample collection kit together with the details of a convenient clinic where you can go and have your sample taken.
Your Thyroid Check UltraVit rT3 includes 1st class postage and packaging for you to send your blood and sample directly to our laboratory for analysis. If you live in an area where you cannot rely on the post or you simply want to ensure that your sample arrives at the laboratory the following day, you may wish to send your blood and sample guaranteed next day delivery for extra reassurance.