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Bone markers are blood and urine tests that help determine if the rate of bone resorption and/or formation is abnormally increased, suggesting a potential bone disorder.
Bone markers are useful in helping to determine a person’s risk of bone fracture and to monitor patients receiving treatment for skeletal disorders, including osteoporosis.
Bone is a living, growing tissue that turns over at a rate of about 10% a year. Throughout a person’s lifetime, old bone is constantly being removed (resorption) and replaced with new bone (formation) to maintain a healthy bone structure.
During bone resorption, cells called osteoclasts dissolve small amounts of bone, while enzymes dissolve the protein network. Bone formation is then initiated by cells called osteoblasts. They secrete a variety of compounds that help form a new protein network, which is then mineralized with calcium and phosphate to produce new bone. This on-going remodeling process takes place on a microscopic scale throughout the body to keep bones alive and sturdy.
We send you an easy-to-use kit to collect your blood sample.
Post your sample to our lab in the prepaid envelope provided.
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Our tests are not a substitute for seeing your doctor, especially if you are suffering symptoms. Our doctors will interpret your results based on the information you have provided, but will not diagnose, consult or provide any treatment. You will be advised to see your doctor for any necessary follow-up action.
Sodium is both an electrolyte and a mineral. It helps regulate the water and electrolyte balance of the body and is important in the operation of nerves and muscles. Sodium levels in the blood are regulated by the kidneys.
Excess sodium in the blood is often due to dehydration but can also indicate that the kidneys are not working properly.
Too little sodium is often caused by fluid retention (oedema) or reflects loss due to vomiting, diarrhoea or excessive sweating.
Chloride, like sodium, helps to maintain the balance of fluid in the body.
Raised levels can caused by eating too much salt, dehydration, diarrhoea, certain medications and also kidney disease.
Low levels can be caused by a condition that causes the ph of the blood to be raised, chronic vomiting and over-hydration.
Urea is waste product produced as the body digests protein and is carried by the blood to the kidneys, which filter the urea out of the blood and into the urine. The urea test examines how well the kidneys are functioning.
Raised levels of urea in the blood can be caused by dehydration or high protein consumption or may indicate that the kidneys are not working properly.
Low amounts of urea in the blood may indicate a low protein diet, excess hydration, malnutrition or liver failure.
Creatinine is a chemical waste molecule that is generated from muscle metabolism. Measurement of this is an indicator of the levels of other waste products in the body. Creatinine is an accurate marker of kidney function.
Elevated creatinine can be caused by high intake of animal protein, taking creatine supplements and vigorous exercise but can also indicate that the kidneys are not working properly.
Low creatinine can be caused by a low protein diet, reduced muscle mass or sometime that the kidneys are simply functioning efficiently.
The estimated glomerular filtration rate (eGFR) assesses how well the kidneys are working by estimating the amount of blood filtered through the kidneys. The glomeruli are tiny filters in the kidneys responsible for removing waste products. If these filters do not do their job properly, kidney function can be impaired. The eGFR calculation is an estimate of actual glomerular filtration rate, calculated using your age, weight, gender, and serum creatinine levels.
A normal or high eGFR indicates good kidney function.
A low eGFR result can indicate your kidneys are not working as well as they should. eGFR can be used to assess the severity of chronic kidney disease (CKD).
It is important to note that individuals with high muscle mass as well as people of certain ethnicities can have a low eGFR which is normal for them. If kidney damage is suspected then other investigative tests are recommended.
Total Protein represents the sum of albumin and globulin. Abnormal levels can indicate malnutrition as well as a liver or kidney disorder.
Albumin is made mainly in the liver and helps to keep the blood from leaking out of blood vessels. It also helps carry some medicines and other substances through the blood and is important for tissue growth and healing.
Low albumin levels can indicate liver disease and can also be a marker for chronic ill-health, malnutrition and inflammation. It can also occur in kidney conditions such as nephrotic syndrome and diabetes.
Raised levels are usually caused by dehydration.
Globulin consists of different proteins and is made by the liver and the immune system. Certain globulins bind with haemoglobin while others transport metals, such as iron, in the blood and help fight infection.
Calcium is the most common mineral in the body and one of the most important. The body needs it to build and repair bones and teeth, help nerves and muscles to function, blood to clot and also help the heart to work. Vitamin D is essential to absorb calcium.
The majority of calcium in the body is stored in bone, the rest is found in the blood. If the calcium result is abnormal, a corrected calcium calculation is carried out to aid further investigation.
Around half of the total calcium in your blood is bound by albumin. Corrected calcium estimates your calcium level assuming albumin is a specified normal value.
Phosphate, also called phosphorus, is an important source of energy. It is a chemical which the body needs to get energy from the food. It is an vital component of bones and high levels are found in skeletal muscle.
We will send you your Bone Screen finger-prick blood, urine test sample collection kit which contains everything you need to take your blood, urine sample in the comfort of your own home. If you are unsure about completing a finger-prick blood sample collection you will have the opportunity to select a clinic-based venous blood sample collection or choose to go our London laboratory during the checkout process.How to collect a finger-prick blood sample
Your Bone Screen test includes 1st class postage and packaging for you to send your blood, urine sample directly to our laboratory for analysis. If you live in an area where you cannot rely on the post or you simply want to ensure that your sample arrives at the laboratory the following day, you may wish to send your blood, urine sample guaranteed next day delivery for extra reassurance.
Your blood, urine sample will be analysed at one of our chosen laboratories. You can be assured of fast, accurate results from one of our accredited independent providers of clinical diagnostic tests.
Our medical team will comment on out-of-range blood, urine test results and give you follow-up advice where necessary. If you need it, a PDF copy of your Bone Screen test results can be downloaded for your doctor.
Once you have placed your order you will receive login details to mymedichecks.com where you can manage your account, track your orders and view your Bone Screen test results.
Stay motivated by filling in your online health and lifestyle questionnaire and seeing how improvements in your lifestyle can influence your test results. Your medical and family history gives us vital information when interpreting your results.