Cancer of the bladder results in approximately 5000 deaths per year in the UK. Risk rises steeply with age, with over half of all deaths occurring in patients aged 70 years or more. The incidence of bladder cancer is three to four times higher in men than women, and roughly twice as high in white men as black men. Cigarette smoking markedly increases the risk for bladder cancer - with nearly half of all new cases of bladder cancer occurring in current or former smokers. Occupational exposure to chemicals used in the dye, leather, tyre and rubber industries has also been associated with an increased risk of bladder cancer. Early detection and treatment may prevent progression to invasive disease or allow for more effective treatment of non-invasive tumours. Regular follow-up testing is required amongst patients treated for early stage bladder cancer because of the high risk of recurrent disease.
Limitations of traditional testing methods have lead researchers to investigate various markers in attempt to develop a simple, non-invasive, but precise, laboratory test.
NMP22 is a protein found in human epithelial cells. In the urine of healthy individuals, the protein is present in low levels (less 10 U/mL). Most patients with bladder cancer release large quantities of NMP22 into the urine.
Like many tunour marker tests, this test is not infallibel. it is possible to have normal levels of NMP22 yet still have bladder cancer. It is also possible to have elevated levels for innocent reasons e.g. extreme exercise prior to the test or a recen cytoscopy. Its use as a screening test is therefore not established and it is more commonly used in the diagnosis of people who have symptoms, or to test for the recurrence of bladder cancer.
This test is for individuals who have been treated for bladder cancer and wish to test for recurrence. It is also for people who are at increased risk due to a history of smoking or exposure to certain chemicals through their work.
We send you an easy-to-use kit to collect your urine sample.
Post your sample to our lab in the prepaid envelope provided.
View results securely in your own personal dashboard.
Please see your doctor if you are suffering any unusual symptoms which persist - do not use these tests to self-diagnose. Tumour markers are most useful when viewed in conjunction with a clinical examination. Results do not constitute a diagnosis of cancer and markers are often tested to monitor treatment when cancer has already been diagnosed, or to check that it has not returned. Cancer markers can be elevated in benign conditions and results often produce false positives. Sometimes tumour markers can be normal even though cancer is present. Please make sure that you think carefully about the risks and benefits before taking this test.
Our tests are not a substitute for seeing your doctor, especially if you are suffering symptoms. Our doctors will interpret your results based on the information you have provided, but will not diagnose, consult or provide any treatment. You will be advised to see your doctor for any necessary follow-up action.
We will send you your NMP22 urine test sample collection kit which contains everything you need to take your urine sample in the comfort of your own home.
Your NMP22 test includes 1st class postage and packaging for you to send your urine sample directly to our laboratory for analysis. If you live in an area where you cannot rely on the post or you simply want to ensure that your sample arrives at the laboratory the following day, you may wish to send your urine sample guaranteed next day delivery for extra reassurance.
Your urine sample will be analysed at one of our chosen laboratories. You can be assured of fast, accurate results from one of our accredited independent providers of clinical diagnostic tests.
Our medical team will comment on out-of-range urine test results and give you follow-up advice where necessary. If you need it, a PDF copy of your NMP22 test results can be downloaded for your doctor.
Once you have placed your order you will receive login details to mymedichecks.com where you can manage your account, track your orders and view your NMP22 test results.
Stay motivated by filling in your online health and lifestyle questionnaire and seeing how improvements in your lifestyle can influence your test results. Your medical and family history gives us vital information when interpreting your results.